It can only help.
As long as the use of instant replay is limited to home runs and close calls of monumental proportion, and doesn't slow down the game, I am 100 percent behind it.
Balls and strikes should still be called by the sometimes fallible eye of the home plate umpire. That's how the game started and that's how it should be. Each ump has a different strike zone and tendency to make certain calls. I like that.
The home run calls need to change. With all the different stadiums using different designs each home run call gets more and more confusing. Home plate doesn't change from stadium to stadium, but each park's outfield wall is completely different.
Hopefully it can make a seamless entry into MLB, and I think it will help the game progress into the 21st century.